Population Pharmacokinetic Parameters of Valproic Acid; Conventional and Slow Release Formulation.

Pharmacokinetic interaction between valproic acid and ertapenem.

An 80-year-old woman with a weight of 74 kg had been primarily diagnosed with complex partial seizures secondary to severe cerebrovascular disease; she also had atrial fibrillation, peripheral artery disease, untreated high blood pressure, and advanced cognitive impairment – she only utters isolated words with a tendency to echolalia. She had an acute thromboembolic stroke two years ago, which ...

Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets.

We investigated the single- and multiple dose pharmacokinetics of a new controlled-release formulation (Orfil retard enteric coated tablet) of valproic acid in comparison with those of the plain tablet as a reference. Twelve healthy volunteers were given each formulation of 300 mg in the single-dose study. In the steady-state multiple-dose study, twelve epileptic patients received 1200 mg/day o...

Influence of Formulation Parameters on the Release of Diclofenace Sodium from Matrices with Manufacturing Formulation Ingredients

Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose...

Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM.

Data from sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium are fitted simultaneously using NONMEM and the general linear model, ADVAN 5. Absorption and disposition parameters, serum levels, and absorption profiles were determined. The in vivo absorption profiles were determined using the program TOPFIT. The in vivo absorption for the s...

Formulation of Population Pharmacokinetic Models of Anti-cancer Agents